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Chronic exposure to outdoor air pollution and lung function in adults

机译:成年人长期暴露于室外空气污染和肺功能

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摘要

Background: The extent to which chronic exposure to outdoor air pollutants influences lung function in adults is unclear. The aim of this study was to measure the association between chronic exposure to outdoor air pollutants and adult lung function.Methods: The relationship between measures of lung function (forced expiratory volume in 1 s (FEV1) and FEV1 as a percentage of forced vital capacity (FVC)) and average exposure to particulate matter <10 μm in diameter, nitrogen dioxide, sulfur dioxide and ozone was examined in four representative cross-sectional surveys of the English population aged ⩾16 in 1995, 1996, 1997 and 2001. Year-specific estimates were pooled using fixed effects meta-analysis.Results: Greater exposure to particulate matter <10 μm in diameter, nitrogen dioxide and sulfur dioxide was associated with lower adult FEV1. The size of the effect on population mean FEV1 was about 3% for particulate matter <10 μm, and 0.7% for nitrogen dioxide and sulfur dioxide, for a 10 μg/m3 increase in pollutant concentration. The effects were most marked in men, older adults and ex-smokers. FEV1 was not associated with ozone concentration. No associations were found between the pollutants and FEV1 as a percentage of FVC.Conclusions: Chronic exposure to outdoor air pollution is associated with modestly reduced FEV1 in adults.
机译:背景:长期暴露于室外空气污染物影响成年人肺功能的程度尚不清楚。本研究的目的是测量长期暴露于室外空气污染物与成年肺功能之间的关系。方法:肺功能量度(1秒钟呼气量(FEV1)和FEV1与强制肺活量百分比的关系) (FVC)),并在1995、1996、1997和2001年对16岁以下的英国人口进行的四次代表性横断面调查中,检查了直径小于10μm的颗粒物,二氧化氮,二氧化硫和臭氧的平均暴露量。结果:采用更大的成人FEV1可以增加对直径<10μm的颗粒物,二氧化氮和二氧化硫的暴露。当污染物浓度每增加10μg/ m3时,对颗粒物<10μm的总体平均值FEV1的影响大小约为3%,对二氧化氮和二氧化硫的影响为0.7%。这种影响在男性,老年人和前吸烟者中最为明显。 FEV1与臭氧浓度无关。结论:长期暴露于室外空气污染与成年人中FEV1的适度降低有关。

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